Simvastatin Modulates Parasitological Response to Sulfadoxine- Pyrimethamine in Acute Uncomplicated Malaria

نویسندگان

  • Ndubuisi N. Nwobodo
  • Paul O. Okonkwo
چکیده

* To whom all correspondence should be addressed. Tel: +234 (0) 703 322 4860; E-mail: [email protected] Parasitological resistance to sulfadoxinepyrimethamine is associated with mutations in parasite dihydrofolate reductase conferring resistance to pyrimethamine and dihydrofolate synthase for sulfadoxine resistance respectively. The prolonged half-life of sulfadoxinepyrimethamine may exert undue pressure for a considerable time following fall of blood concentration below a critical threshold. Poor Simvastatin Modulates Parasitological Response to SulfadoxinePyrimethamine in Acute Uncomplicated Malaria

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تاریخ انتشار 2015